Reversible Non‐Stick Behaviour of a Bacterial Protein Polymer Provides a Tuneable Molecular Mimic for Cell and Tissue Engineering

نویسندگان

  • Ana I. Roque
  • Andrei Soliakov
  • Mark A. Birch
  • Sion R. Philips
  • Deepan S. H. Shah
  • Jeremy H. Lakey
چکیده

Yersina pestis, the bubonic plague bacterium, is coated with a polymeric protein hydrogel for protection from host defences. The protein, which is robust and non-stick, resembles structures found in many eukaryotic extracellular-matrix proteins. Cells grown on the natural polymer cannot adhere and grow poorly; however, when cell-adhesion motifs are inserted into the protein, the cells proliferate.

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عنوان ژورنال:

دوره 26  شماره 

صفحات  -

تاریخ انتشار 2014